36 articles - From Friday Sep 26 2025 to Friday Oct 03 2025
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
| Inflamm Bowel Dis |
|---|
| Menopause and Inflammatory Bowel Disease: A Systematic Review.
Few studies have explored the relationship between menopause and IBD. There is a need for continued research on the relationship between IBD disease activity and menopause symptoms to create tailored interventions to improve women's health with IBD across the lifespan. |
| Pancreatology |
| Prevalence and impact of sarcopenia in chronic pancreatitis: A systematic review and meta-analysis.
This highlights that approximately 41 % of patients with CP have sarcopenia, and that this seems to be associated with a low BMI. Given the known adverse impact of sarcopenia on overall health, future studies should focus on standardizing sarcopenia screening, assessment and exploring its interplay with outcomes in CP patients. Prospero CRD42024611097. |
RCT, clinical trials, retrospective studies, etc…
| Am J Clin Nutr |
|---|
| An observational study on the true indispensable amino acid digestibility of legume protein in infants.
Infants have a high mean IAA digestibility for mung bean protein, although the generalizability of this finding needs to be confirmed. The estimated DIAAS remains low at 50%. In plant-based complementary foods, a ratio of 1 2 of a legume-cereal mix is required to meet protein requirement in infants at this age. |
| Arm circumference as a marker of muscle mass: cutoff values from NHANES 1999-2006.
This study proposes practical MUAC cutoff points, a potential marker of SM, along with BMI adjustment factors for individuals with excess weight, aiming to reduce errors in using MUAC for this purpose. Our results have the potential to enhance clinical routine assessments. |
| Association between dietary fat intake and long-term risk of dementia: a prospective cohort study.
The study demonstrated the heterogeneous associations between different types of dietary fats and risk of dementia. Replacing animal fat and saturated fat with vegetable fat and monounsaturated fats could serve as a dementia prevention strategy. |
| Associations between combined healthy lifestyle and adverse birth outcomes in 2 prospective cohorts: roles of gut microbiota and serum metabolites.
Maternal healthy lifestyle is associated with lower risk of ABOs, with gut microbiota and serum metabolites serving as important mediators in these relationships. |
| Erythromycin plus metoclopramide combination therapy compared with erythromycin or metoclopramide monotherapy for postpyloric spiral nasoenteric tube placement: a multicenter, open-label, randomized controlled superiority trial.
The combination therapy of erythromycin and metoclopramide was not superior to erythromycin or metoclopramide monotherapy in facilitating postpyloric placement of spiral NETs in critically ill patients. However, the combination therapy was associated with a higher incidence of drug side effects compared with the metoclopramide monotherapy. The trial was registered with (trial ID ChiCTR1900022508). |
| Food insecurity may promote opportunistic eating through heightened satiety insecurity: A cross-sectional mega-analysis study.
Satiety insecurity is an unexamined driver of overeating and partially explains why food insecurity motivates opportunistic eating and higher BMI (especially among females). Efforts to mitigate the lasting effects of food insecurity on obesogenic eating behaviors should both restore food access and target insecurities about maintaining satiety. |
| Gut microbiota-derived proinflammatory biomarkers and risk of coronary heart disease: a prospective study among United States males and females.
Higher concentrations of sCD14 may be associated with an increased risk of CHD in females, whereas LBP concentrations are not associated with CHD in either sex. These data do not support that LPS exposure in initially healthy individuals is a contributing CHD risk factor, although the potential sex difference should be explored further. |
| Lanthanum carbonate lowers serum phosphorus without altering body phosphorus burden in maintenance peritoneal dialysis patients: a randomized crossover trial.
Methods Seven adult patients undergoing maintenance peritoneal dialysis underwent full metabolic balance studies for phosphorus in a research ward while they ate a constant phosphorus diet. Patients were studied during a baseline period without phosphate binders and while they received, in random order, 3 doses of lanthanum carbonate (La treatment lowered serum phosphorus concentration but did not change body phosphorus content. |
| Maternal anemia during pregnancy and its association with the gut microbiota profile in pregnant and postpartum women, and their infants: a cohort study.
Our findings reveal a distinct gut microbiota profile in mothers and infants by maternal anemia status. We identified specific taxa that are linked to anemia-related conditions (e.g., iron deficiency) and maternal-infant health outcomes. Future longitudinal studies should explore potential transgenerational associations of maternal anemia with infant microbiota and evaluate whether microbiota-informed interventions, alongside anemia treatments, could improve maternal-infant health outcomes. |
| Measurement error in total energy intake in the United Kingdom National Diet and Nutrition Survey (2008-2015).
We show that although measurement error in estimation of EI is evident within the UK NDNS, it has remained similar. Measurement error was associated with body mass index, age, and sex. |
| New insights into total and resting energy expenditure using state-of-the-art methods in cancer survivors: a cross-sectional study.
The majority of CRCSs exhibit higher energy expenditure than estimated by standard prediction equations, underscoring the need to validate these equations in populations with cancer to optimize accuracy. Improved methods for assessing energy expenditure are needed to guide long-term survivorship care. |
| Nutritional status of children aged 6-59 mo born to mothers treated for severe acute malnutrition in childhood: an observational Lwiro cohort study in Democratic Republic of Congo.
In DRC, children whose mothers had been exposed to childhood malnutrition had a higher prevalence of malnutrition than children born to unexposed mothers. GAM and stunting exceed the extreme severity threshold set by the World Health Organization. |
| Obesity promotes conserved inflammatory and metabolic transcriptional programs in colon tumors: evidence from mouse models and the ColoCare Study Patient Cohort.
These results establish obesity-associated adipose tissue dysregulation as a key intertissue modulator of biology, with concordant cross-species effects on tumor cell-intrinsic inflammatory and metabolic programs. |
| Plasma fatty acids, genetic susceptibility, and colorectal cancer risk: results from a large prospective cohort study.
Plasma PUFAs may have protective effects against CRC, particularly for individuals at high genetic risk. Our study provides novel insights into CRC carcinogenesis and potential preventive strategies. |
| Inflamm Bowel Dis |
| Anti-TNF Therapies Promote a Proximal-to-Distal Healing Pattern in Moderate-to-Severe Ulcerative Colitis.
UC healing follows a proximal-to-distal pattern. Conventional MES remains superior for detecting treatment effects over segmental MES. Further studies should explore alternative endoscopic scoring methodologies. |
| Cognitive Behavioral Therapy for Insomnia May Improve Sleep and Pain in Crohn's Disease: A Waitlist Control Pilot Trial.
This study provides preliminary evidence of efficacy of CBT-I in people with CD. CBT-I improved self-reported sleep and may improve pain and CD symptoms. The results highlight the importance of addressing sleep concerns in inflammatory bowel disease, particularly in people with persistent pain or fatigue. Future trials powered to detect changes in pain and inflammation are warranted. |
| Cross-Sectional Imaging Features Associated With Disease Progression in Crohn's Disease.
Cross-sectional imaging can be used to identify patients with mild CD who are at higher risk for progression. Absence of these features may identify mild CD requiring less aggressive treatment strategies and define a population eligible for trials of management strategies for mild CD. |
| Generation and Phenotypic Analysis of the IL-10RAR104W/R104W Mouse Model.
In summary, we have successfully constructed a humanized mouse model with a stable spontaneous colitis phenotype, which is a valuable model for the therapeutic exploration of VEO-IBD. |
| Genome-Wide Aggregated Trans-Effects Analysis Implicates Deficient Type III Interferon Signaling as a Key Cause of Inflammatory Bowel Disease.
These results implicate down-regulation of Type III interferon signaling as a core pathway in the etiology of inflammatory bowel disease, supported by reports of monogenic inflammatory bowel disease caused by rare loss-of-function variants and by perturbation in experimental models of colitis. Deficient Type III interferon signaling may be amenable to therapeutic intervention. |
| Long-Term Ozanimod Therapy in Patients With Moderately Active Ulcerative Colitis After Failure of 5-Aminosalicylic Acid.
Ozanimod was safe, effective, and durable up to ∼5 years in AT-naive patients with moderate UC who failed conventional therapy. ClinicalTrials.gov NCT02435992, NCT02531126. |
| Perianal Disease Modifiers Are Associated With Less Severe Luminal Disease Activity in Children With Crohn's Disease at Diagnosis.
Perianal fistulizing disease was more common in boys who exhibited milder disease activity, indicating the importance of recognizing perianal fistulizing disease as a clinical clue to the early diagnosis of underlying luminal CD. |
| J Crohns Colitis |
| Drug repurposing approach for the discovery of therapeutic agents for Crohn's disease-associated intestinal fibrosis.
This integrative approach identified potential anti-fibrotic compounds and molecular targets in CD-associated fibrostenosis, supporting future development of effective therapies. |
| Liver Transpl |
| Living donor liver transplantation in infants 6 kg or less: Impact of graft type and size on postoperative outcomes.
LLS grafts frequently demonstrated a favorable thickness ratio ( 4% can be safely used in selected infants, particularly when volumetric compatibility with the native liver is favorable. Preoperative assessment of graft fit, rather than GRWR alone, may provide a more reliable basis for graft selection in pediatric LDLT. |
| Overcoming hepatic artery variations: Arterial reconstruction strategies to expand normothermic machine perfusion in liver transplantation.
Arterial reconstruction prior to NMP is safe and feasible, enabling successful perfusion and transplantation of liver allografts with variant HA anatomy. These findings support the broader application of NMP in anatomically complex donor livers. |
| Reproductive health in the liver transplant recipient.
A key role for transplant team providers lies in pre-conception contraceptive counseling and safety to optimize pregnancy prevention for transplant recipients who do not desire conception. This review highlights the key clinical considerations with practical guidance for counseling and management of reproductive health in LT recipients. |
| Pancreas |
| Proteomic Characterization Reveals CYP2S1 as a Mediator of Drug Resistance in PDAC.
The findings highlight the significant role of CYP2S1 in mediating drug resistance in certain PDAC subtypes. Targeting CYP2S1 and its regulatory pathways could enhance the efficacy of chemotherapeutic agents like irinotecan in treating PDAC. These results provide new insights into the molecular mechanisms underlying PDAC subtype-specific drug resistance and suggest potential therapeutic targets. |
| Pancreatology |
| Clinical predictors of pancreatic fibrosis in patients with recurrent acute and chronic pancreatitis.
Large duct CP, genetic etiology and EPI are al independent predictors of pancreatic fibrosis in a cohort of patients undergoing TPIAT. Computed tomography (CT) imaging and fecal elastase-1 (FE-1) concentration may be sufficient to estimate fibrosis without acquisition of a tissue specimen. |
| Effect of oral rifaximin for prevention of infected pancreatic necrosis and mortality in severe acute pancreatitis: An open-label randomized controlled trial.
Rifaximin did not have a significant effect on either the development of infected pancreatic necrosis or mortality in patients with predicted severe acute pancreatitis. However, the length of hospital stay was significantly shorter in the rifaximin group. Clinical trial registration |
| Elevated expression of circular RNA circ0001415 attenuates acinar cell pyroptosis during acute pancreatitis.
These findings provide novel insights suggesting that the upregulation of circ0001415 may serve as a protective mechanism against the dampening effects on acinar cell pyroptosis following AP. Overall, circ0001415 is a potential molecular target for AP treatment. |
| Identification of A-to-I RNA editing profiles and their clinical relevance in pancreatic neuroendocrine neoplasms.
This study described the landscape of A-to-I RNA editing in pNENs and revealed its relationship with key clinical features including prognosis. The RNA editing-based nomogram provided a novel tool for prognostic prediction, highlighting the potential of RNA editing as a promising biomarker for risk assessment in pNEN patients. |
| Predictors of futile surgery in upfront resectable pancreatic ductal adenocarcinoma. possible targets for neoadjuvant chemotherapy?
Preoperative assessment of resectable PDAC for predictors of disseminated disease may guide the selection of patients suitable for upfront resection or those that may benefit from neo-adjuvant chemotherapy. |
| Total pancreatectomy with islet auto-transplantation in pediatric patients results in significantly decreased opioid use, improved long-term pain and quality of life outcomes.
Utilizing a standardized multidisciplinary approach to TPIAT in pediatric patients with pancreatitis showed significant decreases in opioid use and abdominal pain, regardless of severity of disease, pain, or opioid use pre-TPIAT. |
Plenty of the editorials are available as full text through the publisher website using the provided link
misc publications eg case reports, tools of the trade, images of the month, etc…
| Liver Transpl |
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| Capturing frailty in cirrhosis: Bridging disciplinary gaps, clinical decision-making, and research. |
| Prognostic Communication in Decompensated Cirrhosis: Supporting the Caregiver as a Core Component of Care. |
Letters to the editors and authors’ replies